FREE AMINO ACID METABOLIC PROFILE IN PREGNANCY COMPLICATED BY COVID-19

Background. The unexpected emergence and rapid spread around the world of a new coronavirus infection COVID-19, with large number deaths, has shown importance developing methods for predicting severe course viral infections, creating diagnostic tests, preventive vaccines drugs that act on key factors in progression disease. Clinical studies examining metabolomic changes pregnant women COVID-19 are virtually non-existent. Purpose study. To study features metabolic profile free amino acids during pregnancy complicated by COVID-19. Material methods. concentrations their derivatives blood plasma 86 were studied. main group included 51 confirmed diagnosis COVID-19; control was composed 35 somatically healthy uncomplicated pregnancies. analysis carried out using high performance liquid chromatography. Results. During development infection, protein catabolism predominates, as evidenced an increase concentration 28 venous plasma. We revealed statistically significant cysteine, homocysteine, γ-glutamylcysteine, phosphoserine, cysteine sulfinate, aspartate, homocysteate, glutamate, asparagine, serine, threonine, 1-methylhistidine, glycine, citrulline, arginine, alanine, symmetric dimethylarginine, asymmetric β-aminobutyric acid, γ-aminobutyric tyrosine, valine, methionine, phenylalanine, leucine, isoleucine, lysine, ornithine compared to patients group. Conclusion. will enable us identify additional biomarkers severity disease predict gestation period.